Might reframing biotechnologies in the context of the sacred web of life be useful in guiding innovation towards the creation and restoration of flourishing and generative ecologies? When formulated within the modern paradigm, the products of biotech tend towards the extraction, alienation and entrapment of life, both natural and synthetic. For this episode, we consider biotechnologies within the context of indigineous cosmologies together with Anicka Yi, Lucy Sollitt and Keith Williams.